November 28, 2021

Antihistamine treatment improves hair regrowth

The use of antihistamines in conjunction with a topical corticosteroid (TC) and superficial cryotherapy (SC) in the treatment of alopecia areata (AA) improves the rate of hair growth, according to the results of a study published in the Journal of the American Academy of Dermatology.

Although the understanding of the pathogenesis of AA has advanced in recent years, the optimal therapies have not yet been determined. Antihistamines have been shown to have positive effects when used with topical diphenylcyclopropenone, but their effectiveness in combination with TC and SC treatments has not yet been established.

Data from 148 AA patients who were treated with SC and TC from February 2012 to November 2018 were analyzed. Among the patients included, 24 were also treated with an adjuvant antihistamine. The antihistamines included in the analysis were fexofenadine (180 mg / day for adults and 30 mg / day for children) and ebastine (10 mg / day for adults). There was no significant difference in age, duration of AA, gender, baseline Alopecia Severity Tool score or total follow-up period in the groups. The mean duration of antihistamines use in the treatment group was 6.29 months.

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After about 7 months of treatment, 100% of patients treated with an antihistamine had major hair regrowth and 79.3% of patients not treated with antihistamines had major hair regrowth (P = .045).

The limitations of this study include the small sample size, the difference in sample size between groups, and the lack of investigation into the possibility of a dose-dependent relationship between the use of antihistamines. and the prognosis of the disease.

The results of this study indicated that antihistamine therapy in conjunction with SC and TC therapy is an effective method with no known adverse events. More research is needed, the investigators wrote, to determine whether antihistamines are effective in treating alopecia due to their ability to act as intrinsic histamine H1 receptor antagonists, as well as whether histamines are believed to be effective in treating alopecia. effective monotherapy.


Lee YB, Lee WS. Efficacy of antihistamines in combination with a topical corticosteroid and superficial cryotherapy for the treatment of alopecia areata: a retrospective cohort study. [published online July 15, 2020]. J Am Acad Dermatol. doi: 10.1016 / j.jaad.2020.06.1026

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