December 2, 2022

Arthritis: Antibiotics, Stress, Smoking, and Food Impact Gut Microbiome and Symptoms


Arthritis is a chronic disease characterized by inflammation and pain in the joints that can eventually lead to erosion of bones and cartilage, joint deformity, or loss of mobility. Research suggests that diet may impact the inflammation that causes arthritis pain. In fact, a person’s gut microbiome is so powerful that it could greatly influence disease. With that in mind, what are the four factors that impact your gut microbiome and therefore increase your risk for arthritis and associated symptoms?

A new study has found an unlikely indicator as to whether a person with arthritis can improve their condition or not.

Researchers at the Mayo Clinic Center for Individualized Medicine have found that the answer lies in a person’s gut.

The study found that it would be possible to predict a patient’s future arthritis prognosis by focusing on the trillions of bacteria, viruses and fungi that inhabit the gastrointestinal tract, known as the microbiome. intestinal.

Study co-lead author Dr Jaeyun Sung said, “This is the first study to date that uses gut microbiome data to independently predict clinical improvement in rheumatoid arthritis activity. the initial measurement of their condition or previous treatment. “

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In the study, researchers performed precision genomic analysis on stool samples from 32 arthritis patients.

The team studied the link between the gut microbiome and significant changes in clinical disease activity.

Several traits of the gut microbiome have been shown to be related and may help with future prognosis.

“By examining the basic gut microbiome profiles of patients, we observed significantly different microbiome traits between patients who ultimately showed improvement and those who did not,” said Dr. John Davis, rheumatologist. clinic at the Mayo Clinic.

Dr Sung added, “Ultimately, our study reveals that altering the gut microbiome to improve clinical outcomes may hold promise as a future treatment for rheumatoid arthritis.

“It could revolutionize the way we care for our patients. “


There are many factors that can disrupt a person’s microbiome.

An inflamed intestine can cause problems throughout the body due to inflammatory cells escaping into the bloodstream and moving to other parts of the body.

According to Dr. Jose Scher, a recognized authority on the microbiome and director of the Psoriatic Arthritis Center, the main factors that make your microbiome worse and increase your risk for arthritis are:

  • Antibiotics
  • Smoking
  • Stress
  • Certain foods.

The gut microbiome affects overall health.

An imbalance in the gut microbiome is associated with chronic inflammatory diseases, such as arthritis, as well as other conditions, such as ulcerative colitis.

The best way to maintain a healthy gut microbiome is to maintain a healthy diet.

A dietary change can cause a temporary change in the gut microbiome relatively quickly, but establishing a permanent change is difficult and uncertain.

People who want to reduce arthritis symptoms are advised to make a long-term commitment to a healthy diet that emphasizes whole, plant-based foods.