May 20, 2022

Cranberries may be more effective than antibiotics at fighting URIs


Italian researchers analyzed the effects of postoperative supplementation with cranberry extract Anthocranial phytosome In patients with a history of UTI-R who have been catheterized during surgery. Four weeks after cranberry treatment, no infection or recurrence was reported during the three-month follow-up.

This suggests that supplementation was more effective than antibiotic treatment, the report’s authors said: “It demonstrated a decrease in the appearance of UTI symptoms on the visual analogue scale, the presence of blood cells in the urine and the presence of bacterial contamination in the urine.”

They explain that cranberry extract contains a complex blend of proanthocyanidins (PACs), flavonols, and hydroxycinnamic acids that appear to decrease biofilm formation and reduce inflammation, while postoperative antibiotics can complicate and prolong infection by selecting bacterial strains resistant to antibiotic treatment. and may be ineffective against inflammation.

A recent to studysuggests that a daily intake of 36 mg of PAC helps to decrease urinary tract infections and inflammation of the walls of the urinary tract. This may be relevant in the course of UTIs in which the inflammatory components may be more important than the actual bacterial contamination.

Effect of antibiotics

Recurrent urinary tract infections (UTIs) are common in surgical patients after urinary catheterization but also in non-surgical patients with lower urinary tract abnormalities or anatomical variations, benign prostatic hyperplasia or in patients with partial obstruction. or temporary urinary tract.

Patients are routinely treated with antibiotics, such as nitrofurantoin (recommended by The Infectious Disease Society of America), as a first line of defense to relieve or prevent symptoms associated with UTIs, however researchers argue that antibiotics given to treat infections are sometimes inadequate and can even exacerbate symptoms. “The use of antibiotics during / after surgery can further complicate the infection by selecting bacterial strains that are resistant to antibiotic treatment. R-UTIs can persist for months after surgery if treatment is not adequate.

Frequent or long-term use of antibiotics also has cost and health implications, including drug resistance and reduced effectiveness of antimicrobial treatments.

“The long-term use of nitrofurantoin has been associated with anemia, pulmonary toxicity, liver disease and neuropathy in some patients. R-UTIs are also a major source of morbidity and health costs.

The results of the study suggest that new post-surgical (PS) supplements may offer, “an interesting alternative solution to prevent R-UTI, without using antibiotics“.

Study protocol

The observational study was supervised by the International Agency for Pharma Standard Supplements (IAPSS) and included 64 healthy subjects requiring uncomplicated surgery with urinary catheterization.

Subjects were excluded from the study if significant bacteria were found on the catheter after the operation or if blood was detected in the urine.

Eligible subjects have been assigned to one of two cranberries Anthocranial phytosometreatment groups and received a daily supplement dose of 120 mg or 240 mg; to the control group with standard care (SM) or treated with nitrofurantoin(50 mg three times a day) for four weeks.

Anthocranial phytosome is a cranberry product developed by the nutraceutical company Indena and produced from lecithin. The formulation is designed to improve the delivery of the active ingredients of cranberry to target organs and includes 6-9% PACS and has antioxidant and inflammatory properties.

The occurrence of urinary symptoms was assessed during the four-week follow-up. The presence of urinary tract infections was indicated by specific signs or symptoms (eg, dysuria, nocturia, urge, pain), the presence of an increased bacterial load in the urine, the visible presence of blood in the urine, and need for specialist consultation and assessment.

The results suggest Anthocranial phytosomeProphylaxis is an effective solution to control possible new postoperative and post-catheter urinary tract infections and inflammation in uncomplicated subjects with a history of urinary tract infections, with “Very promising results in the prevention of urinary tract infections both in young healthy subjects and in older men suffering from benign prostatic hyperplasia”.

In addition, researchers testify “The safety and tolerance profile of this product”,due to the total absence of adverse effects.

Source: Dietary Supplement Journal

Posted online: doi.org/10.1080/19390211.2021.1972074

“Anthocran Phytosome: prevention of recurrent urinary tract infections and symptoms after catheterization”

Authors: Roberto Cotellese et al.