May 20, 2022

molnupiravir: Icmr Norms Junk Oral Antivirals, Antibiotics | Bombay News

Mumbai: Oral antivirals such as molnupiravir, antibiotics, monoclonal antibodies and vitamins have no place in India’s latest Covid management guidelines, which were published on the Ministry of Health’s website on Monday. The union.
The antiviral remdesivir, which is given by intravenous infusion, is recommended for moderately to severely ill patients on oxygen support. Off-label use of the rheumatoid arthritis drug tocilizumab continues for patients with severe coronavirus who do not improve on steroids.
The guidelines come just 10 days after ICMR chief Dr Balram Bhargav said Molnupiravir had “safety concerns”.
On Monday, however, the Maharashtra government authorized the use of molnupiravir for a select group of patients with “abundant caution”.
On the omission of Molnupiravir from the management guidelines, many physicians have a different opinion. “The general opinion of the medical community is that this omission is a mistake,” said infectious disease specialist Dr Om Shrivastava, a member of the Maharashtra task force. Maharashtra task force guidelines allow Molnupiravir for patients over the age of 50 with at least two comorbidities and continuous fever for at least three days.
“Physicians should have the discretionary right to prescribe Molnupiravir because there is a subset of patients who benefit from it,” said infectious disease specialist Dr Anita Mathew.
The ICMR guidelines, which were last updated in July 2021, state that patients with mild illness need symptomatic treatment for fever and pain and, if necessary, d a nasal corticosteroid spray (budesonide).
CT scans and expensive blood tests for D-dimer and IL-6 levels are only recommended for moderately and severely ill patients.
Last week, a group of 35 doctors wrote an open letter to Indian health authorities asking for updated guidelines that clearly state the government’s position on new antivirals and monoclonal antibodies so that “unnecessary drugs, tests and hospitalizations “cease.
Dr Satchit Balsari of the Harvard School of Medicine and one of the signatories to the letter said: “It is reassuring to see that the new guidelines are evidence-based and avoid antibiotics. are not available to most people nor are they included. I hope the state agencies that have been distributing drugs en masse will now abandon this practice immediately.
* Oral antiviral medications
* Antibiotics
* Monoclonal antibodies
* Vitamins
* IV antiviral, remidesivir, authorized for “special circumstances”
*Off-label use of tocilizumab, a drug for rheumatoid arthritis
* Steroids, oxygen and steroid nasal spray (budesonide) continue
* Symptomatic treatment with fever medication