December 9, 2022

NSAIDs, antihistamine found in supplement for joint pain


The Food and Drug Administration (FDA) has warned consumers not to purchase or use Pyrola Advanced Joint Formula from GC Natural, a marketed herbal supplement for joint pain.

Laboratory analysis confirmed that Pyrola contained diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), and chlorpheniramine, an over-the-counter (OTC) antihistamine. NSAIDs can increase the risk of cardiovascular events, such as heart attack and stroke, as well as serious gastrointestinal damage (eg, bleeding, ulceration, and fatal perforation of the stomach and intestines). Diclofenac may also interact with other medicines and significantly increase the risk of adverse events, especially in consumers taking several products containing NSAIDs. Antihistamines can cause drowsiness and affect mental alertness.

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Pyrola Advanced Joint Formula is sold on various websites, including, as well as some retail stores.

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