September 22, 2022

Some paracetamol contain “hidden” salt: study | Port Macquarie News

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The “hidden” salt in certain types of paracetamol has been linked to an increased risk of heart disease and death in a large new study. Thanks to safety messages, people are more aware than ever of the salt content of their food. But they may be unaware of the salt levels in some medications they take. Salt is used in some soluble paracetamol because it can help the tablet break down in water. But experts warn that some people may exceed their recommended daily salt limit with a full course of paracetamol containing salt alone. There are now calls for front-of-package warnings for paracetamol containing high levels of salt. The researchers set out to compare the results for people taking soluble paracetamol containing sodium or an effervescent and those taking the salt-free painkiller. The team used data from 790 UK medical practices, which collectively care for 17 million patients. Between 2000 and 2017, they followed people aged 60 to 90 who were prescribed paracetamol containing salt or paracetamol without salt – in the form of tablets, capsules or oral suspension. The international team of researchers followed 300,000 people – half with high blood pressure and half without – for a year. The study, published in the European Heart Journal, found that the risk of cardiovascular disease was higher in those who took paracetamol containing salt. The risk of heart attack, stroke or heart failure after one year for hypertensive patients taking paracetamol containing sodium was 5.6%, compared to 4.6% in those taking paracetamol without sodium. Among those who did not have high blood pressure, the risk of cardiovascular disease after one year was 4.4% in those taking paracetamol containing salt, compared with 3.7% in those taking paracetamol without salt. The risk of death during the follow-up period was also higher in those taking paracetamol with salt. “Because the pain relief effect of sodium-free paracetamol is similar to that of sodium-containing paracetamol, clinicians can prescribe sodium-free paracetamol to their patients to minimize the risk of cardiovascular disease and death,” lead author of the study, said Professor Chao Zeng of Central South University in Changsha, China. “People should pay attention not only to the salt intake in their diet, but also not to overlook the hidden salt intake of medicines in their cupboard.” Our results suggest reviewing the safety profile of effervescent paracetamol and soluble.” In a linked editorial, two experts from the George Institute for Global Health, Australia, said the results were clear. “The direct message of this study is clear – there are likely millions of people in the world who take paracetamol daily in a ‘fast acting’ treatment. effervescent or soluble formulation that increase their risk of cardiovascular disease and premature death,” they wrote. adverse effects of drug-related sodium intake appear likely to increase rather than decrease.” Australian Associated Press

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